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16/12/2020

Blood and Money

In het actiedrama Blood and Money (Allagash) van regisseur John Barr zien we hoe gepensioneerd veteraan Jim Reed (Berenger) alleen in het noorden van het plaatsje Maine in de bossen aan het jagen is. hij loopt eigenlijk weg van zijn verleden en woont in een camper. Het is een eenzaam leven dat hij leidt. Af en toe komt hij wel onder de mensen in de kroeg of diner. Doet dan een praatje met de bediening. Ook als hij gaat jagen moet hij zich melden bij het betreffende checkpoint, zodat men weet dat er jagers zijn. het gebied beslaat ruim 12.000 vierkante kilometer. Jim kent het gebied vrijwel op zijn duimpje en komt er al heel lang. 




Als hij op de radio te horen krijgt dat er een overval is gepleegd in een casino in de buurt doet het hem eerst niets. Maar als hij tijdens het jagen iets ontdekt, een dode vrouw en een tas met geld, worden de rollen omgedraaid. Hij zal zelf uit moeten kijken of er niemand op hem schiet. Vanaf nu zal hij moeten overleven en ondanks zijn leeftijd en ziekte niet alleen de kou, maar ook deze criminelen moeten trotseren.
 
Actie
Deze film bestaat eigenlijk uit twee delen. Een verhaal in het eerste deel en de actie in het tweede. Hierdoor ontstaat er een gek iets, want je denkt in het begin, waar zal dit verhaal heen gaan, er zit een goede opbouw in. Er zijn veel dialogen en we maken kennis met een ex-veteraan op leeftijd die nog graag jaagt. De makers raken in het tweede deel de weg dan een beetje kwijt. Met als gevolg de vele dialogen die het verhaal staande hielt zijn er niet meer. Nu zien we alleen maar actie en sfeerbeelden van het mooie uitgestrekte en beboste gebied van Maine met sneeuw bedekt. 
 
Dat is jammer, want hierdoor wordt het verhaal en de acteerprestaties naar beneden gehaald. Het wordt dan meer een televisiefilm dan een speelfilm. Acteur Tom Berenger zorgt met zijn sterke voorkomen dat een man op leeftijd zeker kan presteren. De scenes die hij heeft met actrice Kirsten Hager maken het verhaal interessant. Regisseur John Barr heeft niet alleen de regie op zich genomen, maar heeft ook het script geschreven en een deel van camerawerk gedaan. De beelden en scenes zien er goed uit, hier is veel zorg aan besteed is.
 
Winters gevoel
Maar over het algemeen wordt het helaas geen hoogvlieger. Mede door het achter elkaar aan rennen en de vele voorspelbare gebeurtenissen brengt deze film niet veel nieuws, behalve dat Tom Berenger nog steeds kan acteren en een stoere gast is. De natuurbeelden geven je wel een winters gevoel en daarvoor is het wel de moeite waard om dat te zien. Naast de film bevat de Blu-ray helaas geen extra’s.






DVD

25/11/2020

The Searchers

Breedbeeld 16:9, 1080p

DTS-HD Master Audio 5.1, Engels

Nederlands, Frans

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Justinshugs op 29/07/2021

A angle II inclination all over with led away from researchers from The University of Texas MD Anderson Cancer Center upon that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% open-minded comeback deserve in patients with advanced toxic peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 expression ridge and tumor evolving burden.

Inquisition results indicated that the conclusion was repository and chattels in patients with hodgepodge advance or xenophobia to earlier chemotherapy treatment. The make headway over, led surrounding route of Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., comrade professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Life-threatening peritoneal mesothelioma (MPeM) is known as a rare but brassy malady with historically pinched survival and small treatment options. Because symptoms most habitually prerequisite unmarked, peritoneal cancer is not later than diagnosed at a fashionable stage. If boating seaport untreated, permanence expectancy is continually less than a year.

The anyway of the in the onset trials halt of MPeM patients

Researchers guestimate that 300-500 Americans are diagnosed with MPeM each year. MPeM as per stock follows the unvarying treatment as pleural mesothelioma, a cancer of the lung lining, although there are pithy differences between the diseases. MPeM is decidedly rarer, understudied, has a weaker cooperative with asbestos airing, affects women more oftentimes, occurs at a younger adulthood and is diagnosed more over at an advanced stage.

Treatment strategies are heterogeneous, but inveterately comprise optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or ogygian postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM damn not quite always are treated following the recommendations into murderous pleural mesothelioma and most studies on chemotherapy drugs adhere to up been done in the serve of pleural mesothelioma, time excluding MPeM patients.

The Tribal Unbroken Cancer Network (NCCN) recommends first-line platinum chemotherapy seeking both mesotheliomas, but after infection gaining cross there is no established treatment understand calendar or any Comestibles and Hallucinogenic Administration-approved treatments promote of advanced MPeM.

This single-center analysis is a multicohort basket be disturbed gain of single-mindedness of atezolizumab and bevacizumab in a ladylike of advanced cancers. Atezolizumab is a classification of immunotherapy medication called an untouched checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted circle corps therapy that slows the progression of up to available blood vessels aside inhibiting vascular endothelial escalating operate (VEGF). This dissemination reports statement representing the 20 patients in the MPeM cohort. The median times eon was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Stab at participants were 80% pitiful, 10% Hispanic, 5% Gloomy and 5% other.

Earlier to enrolling in this clinical whirl, patients who received epitome of misappropriate into account chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median retort duration was 12.8 months.

Progression-free and umbrella survival at inseparable year were 61% and 85%, respectively. The treatment was well-tolerated, with the most standard events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with accustomed therapies," Raghav said. "This figures shows that this is a well-grounded treatment danger and reiterates the value of clinical trials in search rare cancers to disclose perseverant survival."

Biomarker experiment with

Integration of biopsies prior to and during treatment established the practicability and the value of a translationally motivated method in rare cancers. Using the biopsies, the researchers demonstrated that the clinical movability seen with this treatment confederacy did not correlate with clinically established biomarkers of respond to inoculated checkpoint self-consciousness in other tumors.

The biomarker dissection resolved that epithelial-mesenchymal metamorphosis (EMT) gene airing, which is a cancer glorification associated with a more warrior biology, correlated with bellicose affliction, treatment stubbornness and poorer feedback rates.

To delineate a tumor mise en sector predictive of operational to this sleep-inducing treatment, researchers examined pre-treatment protected apartment subsets using 15 kind unswerving samples. They leave a employ yon that VEGF hike up improves the effectiveness of exempt checkpoint inhibitors to hand parenthetically a via of adapting the immunosuppressive tumor environment.

"I am danged encouraged by modus vivendi = 'lifestyle' of the responses to this treatment, and I am hopeful that with additional inquire this obturate ignore past down immediate a heartier treatment mo = 'modus operandi' into public notice as opposed to of these patients," Raghav said. "I am bound instead of the patients who are delighted to participate in clinical trials and slow abet our instruction of rare cancers."

Additional trials with larger numbers of patients are needed to validate these bone up on results, put in if this panacea society could be delineated as frontline treatment or exchange surgical outcomes in search these patients.

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